At the end of the school years 2004/05, Dr Bernhard Bueb -- who had served for 30 years as Head of Schule Schloss Salem -- together with Dieter Plate, long-time Director of Studies and Deputy Head, stepped down. The occasion was marked by a grand farewell ceremony organized by the board of trustees and alumni association (ASV).
Ingrid Sund, Director of Studies at the Deutsche Schule Paris, assumed the overall headship of the Salem schools until the end of the academic year 2005/06.
From 1 January 2007 to 31 August 2011 Prof. Dr. Dr. Eva Marie Haberfellner served as head of school.
From August 2012 until January 2022, Bernd Westermeyer, formerly Rector of Schulpforta, a state-run school founded in 1543 in today's Saxony-Anhalt, has held the position of Headmaster of Schule Schloss Salem.
In 2013, the Salem Kolleg is founded as its own operating company. As a link between school and university, its one-year interdisciplinary programme pursues the goal of providing orientation for high school graduates from all over Germany with regard to their choice of studies and careers.
In 2016, Schule Schloss Salem is invited to join the Global Network of G20 Schools as an outstanding German educational institution. In 2022, Salem will host the organisation's Global Conference.
In 2017, grades 5-10 are merged into double year groups at the Schloss Salem site. This concentration on the founding location is accompanied by the sale of Hohenfels Castle and an investment programme of over 20 million euros (expansion of the sports field, conversion of the Margravial Riding Hall into a second sports hall, structural expansion of the Natural Sciences, general renovation of the Rentamt for grades 5 & 6. Creation of additional wings and a study hall in the central axis of the castle, creation of an additional dining hall for grades 5-8 and a new building with guild workshops, classrooms for grades 7 & 8 and an auditorium with 350 seats).
From 2019, the school will equip all classrooms with uniform state-of-the-art IT hardware. In addition, MS Office 365 will be made available to all students and staff, a software package that is proving its worth with the onset of the Corona pandemic.
In 2019, Schule Schloss Salem officially becomes a partner school of the 20 July 1944 Foundation and honours its alumnus Hans-Ulrich v. Oertzen with a stumbling stone at Schloss Spetzgart the following year.